Clustering-based visualizations for diagnosing diseases on metagenomic data

Abstract

Metagenomic data has recently become crucial for precision or personalized medicine. However, these data are often complex, challenging to observe and require sophisticated visualization approaches such as clustering algorithms. Additionally, leveraging the robustness of a simple deep learning architecture, such as a shallow convolutional neural network, has attracted many scientists. Therefore, this study utilized well-known clustering algorithms such as density-based spatial clustering of applications with noise (DBSCAN), balanced iterative reducing and clustering using hierarchies (BIRCH), and ordering points to identify the clustering structure (OPTICS) to identify patterns in complex data and generate visualizations from species abundance composition of various diseases. The study then integrated a shallow convolutional neural network to perform disease prediction tasks on clustering-based visualizations. Experimental results showed that BIRCH outperformed some studies in diagnosing Type 2 diabetes, while DBSCAN performed well in diagnosing Colorectal cancer and Inflammatory Bowel Disease.

Centennial Changes of Salt Marsh Area in Coastal Georgia (USA) Related to Large-Scale Sediment Dynamics by River, Waves, and Tides

Abstract

Marsh lateral expansion and retreat are often attributed to sediment availability, but a causal link is difficult to establish. To shed light on this problem, we analyzed changes in salt marsh area along the ~ 200-km-long Georgia coast (USA) from the 1850s to 2010s in relation to total suspended sediment (TSS) and to proxies for river sediment input and local sediment resuspension. Marsh area is characterized by large gains and losses (up to 200 m2/m/yr), but relatively small net change (-50 to 50 m2/m/yr or -0.1 to 0.1%/yr). This has resulted in a general loss of marsh area, except close to the mouths of major rivers, where there is net gain. Net expansion rates decreased in the Savannah Estuary but increased in the Altamaha Estuary from the 1850s–1930s period to the 1930s–2010s period, which are consistent with observed decreases and likely increases in sediment discharge in the two estuaries, respectively. To explain the spatial patterns in the 1930s–2010s marsh area change, we estimated TSS from satellite measurements (2003 to 2020). Along the northern part of the Georgia coast, net marsh gain is positively correlated to the average TSS within the estuarine region. However, this correlation breaks down in more southern areas (Cumberland Sound). Coast-wide, there is a better correlation between TSS associated with new input from the rivers, estimated as the TSS difference between high-discharge (Jan–Mar) and low-discharge (Sept–Nov) months. To identify the effect of wave resuspension in the nearshore, we consider the TSS difference between high-wave, low-discharge (Sept–Nov) and low-wave, low-discharge periods (Jun–Aug). Wave resuspension is relatively uniform along the coast and does not explain spatial patterns of marsh area change. Sediment input from the nearshore is likely contributing to the estuarine sediment budget in Georgia, but it is not sufficient to prevent marsh lateral retreat. To identify the role of tidal resuspension and advection, we consider differences in TSS between low and high tide. This differential is relatively constant along most of the coast, but it is much lower in the southern part of the coast, suggesting a lower tidal action in this region. Sediment resuspended by tides is likely originating from internal recycling (i.e., erosion) within the estuary, and thus does not contribute to marsh lateral expansion. The proposed approach to partition TSS is a general demonstration and could be applied to other coastal regions.

The Predictability Limit of Oceanic Mesoscale Eddy Tracks in the South China Sea

Abstract

Employing the nonlinear local Lyapunov exponent (NLLE) technique, this study assesses the quantitative predictability limit of oceanic mesoscale eddy (OME) tracks utilizing three eddy datasets for both annual and seasonal means. Our findings reveal a discernible predictability limit of approximately 39 days for cyclonic eddies (CEs) and 44 days for anticyclonic eddies (AEs) within the South China Sea (SCS). The predictability limit is related to the OME properties and seasons. The long-lived, large-amplitude, and large-radius OMEs tend to have a higher predictability limit. The predictability limit of AE (CE) tracks is highest in autumn (winter) with 52 (53) days and lowest in spring (summer) with 40 (30) days. The spatial distribution of the predictability limit of OME tracks also has seasonal variations, further finding that the area of higher predictability limits often overlaps with periodic OMEs. Additionally, the predictability limit of periodic OME tracks is about 49 days for both CEs and AEs, which is 5–10 days higher than the mean values. Usually, in the SCS, OMEs characterized by high predictability limit values exhibit more extended and smoother trajectories and often move along the northern slope of the SCS.

The only living guerrillero in New York: Cuba and the brokerage power of a resilient revisionist state

Abstract

This article explores how weak countries deflect systemic pressure towards change and even succeed in preserving old institutions to their advantage. By expanding Goddard’s theory of embedded revisionism to smaller powers, the study identifies strategies these states deploy to improve access and brokerage. We use the UN General Assembly Sponsorship Dataset to locate multilateral brokers and, after detecting Cuba’s centrality in this arena, we proceed to a heuristic case study. Havana’s maneuvers to offset its vulnerability during and after the Cold War reveal a mix of structural, institutional, and compulsory power. Specifically, its renewal of the Non-Aligned Movement even after the end of bipolarity, its maintenance of autocracy amidst the pressures for democratization, and later support of radicalized Latin American leaders provide insight regarding unexpected sources of network power available to a resilient rogue state.

The power of the “weak” and international organizations

Abstract

By nearly every measure, power in the international system is concentrated, meaning that most states lack significant power resources. And yet international relations theory tends to focus on the behavior of great powers. This special issue instead explores the strategies that “weak” states use in the context of international organizations both to advance their interests and to resist pressure from stronger states. We define weakness as a relative lack of power across one or more dimensions. While the literature, to the extent it has focused on weak actors, has too often defined weakness solely in material terms, we adopt a broader conception that builds on the influential typology of power by Barnett and Duvall (Barnett and Duvall, 2005a, Barnett and Duvall, International Organization 59, 39–75, 2005b). A multidimensional conceptualization of power allows analysts to show how actors that are weak in one dimension (often material power) may be stronger on other dimensions, giving them greater capacity for action than is often recognized. From this framework we create a typology of “strategies of the weak” that emphasizes the agency of weaker actors to make the most of their positions. The contributions to the special issue, summarized here, illuminate and substantiate many of these strategies across a diverse range of international organizations, understood as both forums and actors. As the articles show, these alternative theoretical mechanisms help explain how and why seemingly weak states sometimes fare better than a simplistic assessment of their material capabilities might suggest. By deepening our understanding of weakness and how it influences state behavior, the volume advances our theoretical understanding of how power is built, wielded, and resisted in and through international organization.

Exploring the impact of establishment mode on intangible strategic asset creation in Chinese MNEs: springboard cross-border strategic asset-seeking M&As versus greenfield R&D-related FDI projects

Abstract

How does greenfield versus M&A FDI establishment mode influence intangible asset creation in the parent companies of Chinese MNEs undertaking overseas knowledge sourcing/strategic asset-seeking types of FDI? We hypothesise that while springboard type cross-border acquisitions provide opportunities for the rapid addition of locally embedded competence-creating foreign subsidiaries, challenges in developing intra-MNE knowledge diffusion channels may frustrate integration and thus retard subsequent growth of parent firms’ intangible assets. Greenfield R&D FDI, by contrast, may initially lack local embeddedness but holds out the potential for superior intra-MNE linkages and thus reverse knowledge diffusion to the MNE parent. Our results, based upon propensity score matching and difference in difference models comparing CMNE parent outcomes for FDI projects over the 2003–2018 period, support this argument. We discuss implications for mainstream international business theorising, including springboard theory, which largely overlooks greenfield establishment mode as a means of rapid firm-level catch-up for emerging market MNEs.

Dietary Magnesium Intake and Proteinuria: Is There a Relationship?

Abstract

The possible relationship between dietary magnesium status and proteinuria has been suggested by a number of previous studies. However, human studies on this association are limited. Therefore, the present study aimed to investigate the independent relationship between dietary magnesium intake and urinary protein excretion. The present study was a post hoc analysis of the previous randomized clinical trial that evaluated the effect of dietary phosphorus restriction on proteinuria. The baseline data of 90 participants with proteinuria and chronic kidney disease was used to measure the association between dietary magnesium intake and proteinuria. Participants were asked to record their 24-h food intake for three days a week in a questionnaire. Urinary protein to creatinine ratio (UPCR) in a random urine sample was measured to be a marker for proteinuria. Out of 90 patients included in the study, 47 were men and 43 were women. The mean ± standard deviation of age and body mass index were 59.05 ± 14.16 years and 29.02 ± 5.54 kg/m2, respectively. The patients’ average daily dietary intake of energy and magnesium were 2183 kcal and 169.44 mg, respectively. A significant inverse correlation was found between the dietary intake of magnesium and UPCR (r =  − 0.219, p = 0.042). This association remained significant even after adjusting for confounding variables (β =  − 0.222, p = 0.028). The findings of the present study showed a significant inverse relationship between the magnesium intake and proteinuria. Although, the design of the current research was cross-sectional, it has provided a basis for conducting future longitudinal studies and trials to better elucidate such a relationship.

Foreign bank entry and the outward foreign direct investment of companies: evidence from China

Abstract

Globalization is motivating many emerging market firms (EMFs) to expand operations through outward foreign direct investment (OFDI). General FDI theories, such as internalization theory and the OLI paradigm, are based on industrialized countries, leading to inevitable gaps in explaining the OFDI activities of EMFs. We extend the literature by establishing a connection between international finance and the internationalization of EMFs. We argue that foreign banks operating in emerging markets offer a diverse set of resources that can help EMFs expand globally. Under gradually easing foreign bank entry restrictions in China, utilizing a panel dataset of Chinese listed companies spanning 2001–2018, we find a positive association between foreign bank entry and the OFDI activities of Chinese companies. The identified channels include direct loan support from foreign banks, information support from foreign banks’ global branch networks, a high level of internationalization, and close proximity to local companies, as well as loan support from domestic banks under foreign bank competition. The entry of foreign banks particularly stimulates OFDI in non-state-owned, higher profitability companies, in medium-sized, low financial marketization, and node cities designated in the Belt and Road Initiative. These findings provide new insights into emerging market financial openness and the internationalization of EMFs.

Institutional distances and equity-based entry modes: a systematic literature review

Abstract

The institutional distance between home and host countries influences the benefits and costs of entry into markets where a firm intends to conduct business. Entry mode choice is a function of a firm's strategy to increase its competitiveness, efficiency, and control over resources that are critical to its operations. This systematic literature review aims to explain the influence of institutional distances on equity-based entry modes in international markets. The present study contributes to the literature on international business using institutional theory to address the entry mode, and by analyzing the nature of the constructs used to measure the influence institutional distances have on the choice of entry mode into foreign markets.

International business and decentralized finance

Abstract

Over the last decade, the green shoots of a new economic order have emerged as decentralized technologies challenge traditional financial systems. Decentralized finance (DeFi) holds the potential to transform international business (IB) by offering accessible financial services across borders, disrupting traditional intermediaries, and promoting financial inclusion. While traditional fintech has challenged banks, DeFi operates outside legacy systems, leveraging blockchain technology and smart contracting to introduce a new range of products and services that provide first-movers with an upper hand to both expand their business across the globe as well realize cost savings on existing business. Despite offering advantages like efficiency, transparency, and security, DeFi faces regulatory uncertainties and scalability, adoption, and stability concerns. Our study explores how DeFi can seamlessly integrate into the IB space while addressing these challenges. In addition to offering insights for investors, multinational firms, and regulators, we also lay the groundwork for future IB research in the fintech domain. As the DeFi innovation unfolds, understanding and harnessing its potential can empower stakeholders to engage responsibly and effectively in this transformative landscape.