Evolving Toward Community-Based Participatory Research: Lessons Learned from a Mindful Parenting Project

Abstract

Objectives

Much of the research involving mindfulness, meditation, and other awareness-based interventions have repeated many historical patterns in non-participatory research that exclude Black communities and perpetuate racial hierarchies. A shift toward community-based participatory research (CBPR) approaches is critical to facilitating authentic community partnership and advancing racial equity. The objective of this case study was to describe the evolution of a research-practice partnership within a parent mindfulness intervention study, which took place at a predominantly Black school community, as the project team increasingly incorporated CBPR principles into the project.

Method

Following pilot phase, the project team (including researchers, mindfulness teachers, and project staff) along with a cohort of prior participants engaged in a series of facilitated reflective discussions and semi-structured interviews. These discussions examined various challenges within the research-practice partnership and the principles of CBPR that alleviated these challenges, to highlight key lessons learned from critical phases of the project.

Results

The case study demonstrates that applying CBPR principles cultivated an enhance sense of authentic partnership in key phases of the project: developing a theory of change (TOC) and evaluation strategy; assembling project team roles and responsibilities; measure selection, data collection and interpretation; and during dissemination efforts.

Conclusions

Our lessons learned demonstrate how a commitment to CBPR principles can culminate in an intervention and evaluation process grounded in racial equity and help build community investment in mindfulness research.

A practical tool to enable Indigenous enterprise planning and development grounded in culture

Abstract

Globally, Indigenous people seek to develop sustainable livelihood options that enable them to practice their culture, look after their traditional estates and generate economic development outcomes for their wider community. Enterprise development can and may provide one such pathway. However, challenges can arise with regard to reconciling the core drivers of ‘economic development’ with aspirations to practice and preserve culture. Current enterprise development approaches and models do not always suit Indigenous contexts. In this paper, we present a practical tool to enable Indigenous leaders, their partners, and others, to consider enterprise development options grounded in culture that may generate multiple benefits including economic outcomes. Our tool combines critical review of alternative development models, with empirical research to outline a set of foundational principles, building blocks and potential enterprise development options. We apply the practical tool to a case study of a nascent enterprise from the northern Australia Indigenous-led bush products sector. The case study illustrates how enterprise development planning is integral and discussions should consider how to enable cultural governance, protection of Indigenous cultural and intellectual property, potential benefits and sharing, access to resources, as well as the ‘building blocks’ for enterprise development and consideration of different enterprise approaches. The practical tool aims to ensure development pathways build on local economies and ecologies, do not compromise culture and recognise the influence of extra-local political economies on lived experiences and outcomes.

AI chatbots contribute to global conservation injustices

Abstract

Artificial Intelligence (AI)-driven language models (chatbots) progressively accelerate the collection and translation of environmental evidence that could be used to inform planetary conservation plans and strategies. Yet, the consequences of chatbot-generated conservation content have never been globally assessed. Drawing on distributive, recognition, procedural, and epistemic dimensions of environmental justice, we interviewed and analysed 30,000 responses from ChatGPT on ecological restoration expertise, stakeholder engagements, and techniques. Our results show that more than two-thirds of the chatbot’s answers rely on the expertise of male academics working at universities in the United States, while largely ignoring evidence from low- and lower-middle-income countries (7%) and Indigenous and community restoration experiences (2%). A focus on planting and reforestation techniques (69%) underpins optimistic environmental outcomes (60%), neglecting holistic technical approaches that consider non-forest ecosystems (25%) and non-tree species (8%). This analysis highlights how biases in AI-driven knowledge production can reinforce Western science, overlooking diverse sources of expertise and perspectives regarding conservation research and practices. In the fast-paced domain of generative AI, safeguard mechanisms are needed to ensure that these expanding chatbot developments can incorporate just principles in addressing the pace and scale of the worldwide environmental crisis.

Long Covid: A Syndemics Approach to Understanding and Response

Abstract

Nearly one in five U.S. adults are impacted by long Covid. The health, social, and economic burdens of long Covid are complicated and trying. Although the causes of long Covid remain uncertain, emerging research suggests an infectious disease origin for at least some portion of cases. We draw on a grey and white literature, media reports, and postings on forums to examine the shared experiences of long Covid and the present argument for pathogen-pathogen interactions. Data suggest that long Covid disproportionately impacts communities that already experience disparities in health, specifically lower-educated, low-income, women of working age and minority ethnic groups as they have greater exposure to COVID-19 initially and experience the symptoms of long Covid more severely. Among these individuals, COVID-19 can play a role in reactivating viruses already present in the body (specifically herpesviruses) which accumulate over the course of a lifetime and generally persist in a dormant state. As such, long Covid may present as a syndemic in some communities – the clustering of synergistically interacting diseases, a consequence of deleterious social conditions. The syndemic nature of long Covid requires a syndemic response to address the intersecting social and biological drivers. At the population level, considerations of the social factors, disease co-morbidities including those dormant or yet to be diagnosed, need to be integrated into treatment protocols and public health responses.

Long Covid: A Syndemics Approach to Understanding and Response

Abstract

Nearly one in five U.S. adults are impacted by long Covid. The health, social, and economic burdens of long Covid are complicated and trying. Although the causes of long Covid remain uncertain, emerging research suggests an infectious disease origin for at least some portion of cases. We draw on a grey and white literature, media reports, and postings on forums to examine the shared experiences of long Covid and the present argument for pathogen-pathogen interactions. Data suggest that long Covid disproportionately impacts communities that already experience disparities in health, specifically lower-educated, low-income, women of working age and minority ethnic groups as they have greater exposure to COVID-19 initially and experience the symptoms of long Covid more severely. Among these individuals, COVID-19 can play a role in reactivating viruses already present in the body (specifically herpesviruses) which accumulate over the course of a lifetime and generally persist in a dormant state. As such, long Covid may present as a syndemic in some communities – the clustering of synergistically interacting diseases, a consequence of deleterious social conditions. The syndemic nature of long Covid requires a syndemic response to address the intersecting social and biological drivers. At the population level, considerations of the social factors, disease co-morbidities including those dormant or yet to be diagnosed, need to be integrated into treatment protocols and public health responses.

Exploitation of the ensemble-based machine learning strategies to elevate the precision of CORDEX regional simulations in precipitation projection

Abstract

Multi-model Ensembles (MMEs) are widely used to reduce uncertainties associated with simulations and projections of GCM/RCM.MMEs combine the results of multiple climate models to produce a more robust and reliable prediction. By considering the range of outputs from different models, MMEs can improve the overall accuracy of climate projections. Therefore, the study focused on the use of some techniques, namely Multivariate Linear Regression (MLR), Weighted Average (WA), and some ML algorithms including Least Square Support Vector Machine (LS-SVM), Random Forest, (RF) and multivariate adaptive regression splines (MARS) to develop MMEs to simulate precipitation patterns over Iran. The regional climate models (RCMs) used in this research were extracted from the South Asia Coordinated Regional Climate Downscaling Experiments (CORDEX-SA) dataset. By comparing the individual RCMs and MMEs developed using the proposed methods, it was found that MMEs improved their capabilities compared to individual RCMs in their ability to simulate precipitation patterns. Furthermore, the study revealed that the MME developed using RF (MME-RF) exhibited more consistent performance across different spatial regions compared to other methods, especially WA technique, which displayed the lowest performance in comparison to other methods. Regarding the projections of seasonal precipitation under RCP4.5 and RCP8.5 scenarios, a potential decrease (roughly 6.5%) in precipitation in the western regions during autumn season, was observed. Whereas, the southern and southeast regions of Iran in particular showed a pronounced wetting tendency during the autumn season. According to the forecasts, the maximum percentage change (PC) of precipitation in these regions is expected to increase by 13.88%.

Current status of optoacoustic breast imaging and future trends in clinical application: is it ready for prime time?

Abstract

Optoacoustic imaging (OAI) is an emerging field with increasing applications in patients and exploratory clinical trials for breast cancer. Optoacoustic imaging (or photoacoustic imaging) employs non-ionizing, laser light to create thermoelastic expansion in tissues and detect the resulting ultrasonic emission. By combining high optical contrast capabilities with the high spatial resolution and anatomic detail of grayscale ultrasound, OAI offers unique opportunities for visualizing biological function of tissues in vivo. Over the past decade, human breast applications of OAI, including benign/malignant mass differentiation, distinguishing cancer molecular subtype, and predicting metastatic potential, have significantly increased. We discuss the current state of optoacoustic breast imaging, as well as future opportunities and clinical application trends.

Clinical relevance statement

Optoacoustic imaging is a novel breast imaging technique that enables the assessment of breast cancer lesions and tumor biology without the risk of ionizing radiation exposure, intravenous contrast, or radionuclide injection.

Key Points

• Optoacoustic imaging (OAI) is a safe, non-invasive imaging technique with thriving research and high potential clinical impact.

• OAI has been considered a complementary tool to current standard breast imaging techniques.

• OAI combines parametric maps of molecules that absorb light and scatter acoustic waves (like hemoglobin, melanin, lipids, and water) with anatomical images, facilitating scalable and real-time molecular evaluation of tissues.

Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas

Abstract

Three-dimensional (3D) geometrical models are potent tools for quantifying complex tissue features and exploring structure–function relationships. However, these models are generally incomplete due to experimental limitations in acquiring multiple (> 4) fluorescent channels in thick tissue sections simultaneously. Indeed, predictive geometrical and functional models of the liver have been restricted to few tissue and cellular components, excluding important cellular populations such as hepatic stellate cells (HSCs) and Kupffer cells (KCs). Here, we combined deep-tissue immunostaining, multiphoton microscopy, deep-learning techniques, and 3D image processing to computationally expand the number of simultaneously reconstructed tissue structures. We then generated a spatial single-cell atlas of hepatic architecture (Hep3D), including all main tissue and cellular components at different stages of post-natal development in mice. We used Hep3D to quantitatively study 1) hepatic morphodynamics from early post-natal development to adulthood, and 2) the effect on the liver's overall structure when changing the hepatic environment after removing KCs. In addition to a complete description of bile canaliculi and sinusoidal network remodeling, our analysis uncovered unexpected spatiotemporal patterns of non-parenchymal cells and hepatocytes differing in size, number of nuclei, and DNA content. Surprisingly, we found that the specific depletion of KCs results in morphological changes in hepatocytes and HSCs. These findings reveal novel characteristics of liver heterogeneity and have important implications for both the structural organization of liver tissue and its function. Our next-gen 3D single-cell atlas is a powerful tool to understand liver tissue architecture, opening up avenues for in-depth investigations into tissue structure across both normal and pathological conditions.

The consequences of the 2017 US international tax reform: a survey of the evidence

Abstract

The 2017 US tax legislation—widely referred to as the Tax Cut and Jobs Act (TCJA)—fundamentally transformed the US system of international taxation. It ostensibly ended worldwide taxation but introduced, for instance, a new tax on “Global Intangible Low-Taxed Income”. This paper surveys the emerging empirical literature on the impact of the TCJA’s international provisions. It documents five robust findings in this empirical literature. First, the TCJA led to a general decline in US MNCs’ foreign acquisitions. Second, the TCJA increased US MNCs’ investment in routine foreign tangible assets. Third, the reform did not lead to any change in profit shifting by US MNCs beyond the magnitude that would be expected based on the TCJA’s tax rate reduction. Fourth, The TCJA appears to have reduced the market value of US MNCs relative to domestic US firms. Fifth, the TCJA does not appear to have had any detectable impact on domestic US investment and wages (although there are some contrary results for capital expenditures). The welfare implications of these findings depend crucially on whether US MNCs’ are viewed as having engaged in too much or too little foreign activity prior to the TCJA. This depends on the choice of theoretical framework and the relevant normative benchmark, and cannot readily be resolved empirically.

Comparative study of computational frameworks for magnetite and carbon nanotube-based nanofluids in enclosure

Abstract

Multi-wall carbon nanotubes (MWCNTs) characterize innovative nanoparticles that progress the thermal characteristics of base fluids, compelling them appropriate for utilizing in renewable energy, heat exchanger, and automotive engineering. In this analysis, the buoyancy-driven flow in a superposed spherical enclosure packed with amalgamated porous (Fe3O4-MWCNTs/H2O) hybrid nanofluid layers was explored by employing the procedure of Levenberg–Marquardt with backpropagated artificial neural networks (LMB-ANN) for two temperature models. The exterior wall of enclosure was kept at a constant frigid condition, while the inner surface received partial heating to create a heat flux. The flow situation within the porous cavity was modeled using the Darcy–Boussinesq model. To evaluate the model equations, the control volume-based finite element method (CVFEM) was adopted. The results obtained from numerical method explain the reference data of LMB-ANN for several situations of porous cavity by modifying model variables. By varying the model parameters within the scope of the present numerical approach, a set of proposed data LMB-ANN is generated for cases. The proposed model has equaled for perfection after the numerical findings of various instances have been evaluated using the LMB-ANN train, test, and validating strategy. Several error graphs and statistical visualizations focused on mean square errors, error histogram, and regression assessment are designed to support the proposed methodology (LMB-NN). The proposed approach (LMB-ANN) has been verified based on the correlation of the suggested and benchmark (numerical) outputs, with a validity level ranging from 10–02 to 10–09. Also, the principal findings revealed that elevating the Rayleigh and Darcy numbers improves energy transmission inside the enclosure.